T3P

(Propylphosphonic Anhydride)

Other Names:

1-Propanephosphonic anhydride

General Information:

Structure:

CAS Number: 68957-94-8

Molecular Weight: 318.18 g/mol

T3P is typically sold as a 50% solution in a solvent (ex. EtOAc or DMF).

Common Uses:

Reagent for amide couplings

Procedure excerpt:

. . . To the solution was added T3P in 2-Me-THF (9.176 kg, 9.176 L of 50% w/w, 14.42 mol) over 30-45 min, resulting in a light amber solution. After 2 h, the reaction . . .

[full procedure]

References:

1) Patent Reference: WO2015089361, page 75, (5.2 MB)

2) www.sigmaaldrich.com: Propylphosphonic anhydride solution (link)